Early B-cell factor-1 (EBF1), a transcription factor that is expressed in early stages of B cell differentiation, regulates important steps in the specification of B cells. By the targeted inactivati...

Activation of genes involves changes in chromatin structure and interactions between enhancers and promoters. We have been studying the expression of immunoglobulin genes as a model for cell type sp...

LEF1/TCF proteins have been identified as transcriptional mediators of the Wnt signaling pathway. This pathway represents one of the major regulatory determinants of mouse development and its deregu...