DEPARTMENT OF MOLECULAR IMMUNOLOGY
Research of the Department of Molecular Immunology seeks to better understand the organisation and regulation of intracellular signalling pathways in normal and diseased lymphocytes. Research of the Department is traditionally focused on the B lymphocyte although recently we have extended our studies to signalling pathways in mast cells and to structure/function studies of the T cell antigen receptor. We have developed several model systems for studying protein-protein interactions between leukocyte receptors and their signalling components.
In collaboration with the University of Freiburg and the MPI, the Department organizes an advanced study of molecular immunology. This program started in 1997 and has become very popular, attracting students from Freiburg and other Universities.
  Laboratory Reth
| | | Our research interests focus on intracellular signalling pathways in B lymphocytes.
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Laboratory Jumaa
| | | The aim of my research group is to obtain a global understanding of the signaling pathways that regulate the proliferation and differentiation of B cells. Signals emanating from the B cell antigen receptor (BCR) or its precursor (pre-BCR) lead to changes in gene expression and determine the fate of developing B cells.
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Laboratory Nielsen
| | | We are interested in the regulation of gene expression during B-cell development. We are studying the influence of the transcriptional activator protein Bob1/OBF1/OCA-B in pre B-cells. In a second project, we examine the effect of somatic recombinations in the immunoglobulin kappa locus on immunoglobulin lambda recombination.
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Laboratory Schamel
| | | T cell activation after antigen-recognition is the crucial event in the initiation of an immune response. We are interested in the molecular mechanisms of this activation and how this knowledge can be useful for treatments of human diseases.
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Department of Molecular Immunology
